IRAP II™ System

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Defects in articular cartilage can induce osteoarthritis by causing molecular changes in the synovial fluid. Research in molecular biology discovered the major inducer of osteoarthritis was the general inflammatory cytokine interleukin-1 (IL-1) which plays a key role in accelerating tissue destruction and the repair mechanisms.

In a healthy joint, IL-1 and interleukin-1 receptor antagonist (IL-1Ra) are in balanced concentrations. In cases of osteoarthritis, there is not sufficient IL-1Ra produced to block the destructive effects of the increased IL-1. The result is inflammation, joint pain, and eventually cartilage destruction. In the IRAP II system, monocytes (a type of white blood cell) bind to the glass beads. The cells are then stimulated to produce regenerative and anti-inflammatory proteins without the addition of drugs. This process takes place over an incubation period of 24 hours.

IRAP II is used to treat mild to moderate osteoarthritis in animals.

Surgical Technique Videos (1)
- - ARTHREX VET SYSTEMS IRAP II
  - File Type:
  - Ref. #: VVID1-01134-EN
  - Version: A
  - Language: English
  - Revision Date: 07/25/2017
  - Presenter: Hank Gendron, DVM
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Surgical Technique Animations (1)
- - IRAP II™ Autologous Blood Processing System
  - File Type:
  - Ref. #: AN1-00240-EN
  - Version: A
  - Language: English
  - Revision Date: 07/03/2017
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Brochures (2)
- - Arthrex IRAP™ ProEAS™ System Surgical Technique
  - File Type:
  - Ref. #: vLB1-000002-en-US
  - Version: C
  - Language: English
  - Revision Date: 07/26/2021
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- - The IRAP II System - Autologous Blood Processing System
  - File Type:
  - Ref. #: VLB1-0010-EN
  - Version: E
  - Language: English
  - Revision Date: 10/21/2019
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White Papers (4)
- - Comparison of Equine IRAP ProEAS™ Device, IRAP II, and Pro-Stride Using Equine-Specific ELISAs
  - File Type:
  - Ref. #: vLA1-000004-en-US
  - Version: A
  - Language: English
  - Revision Date: 11/29/2018
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- - Arthrex^® IRAP II System
  - File Type:
  - Ref. #: VLA1-0010-EN
  - Version: D
  - Language: English
  - Revision Date: 06/28/2017
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- - IRAP II (ABPS): Vertical vs. Horizontal Incubation, Serum Color Differences
  - File Type:
  - Ref. #: VLA1-0011-EN
  - Version: A
  - Language: English
  - Revision Date: 05/08/2017
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Presentation Videos (1)
- - Use of Biologics in Small Animal Orthopaedics
  - File Type:
  - Ref. #: VVPT1-00921-EN
  - Version: A
  - Language: English
  - Revision Date: 07/26/2017
  - Presenter: James L. Cook, DVM, PhD
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Catalogs (1)
- - Vet Systems Product Catalog
  - File Type:
  - Ref. #: VLB1-0001-EN
  - Version: H
  - Language: English
  - Revision Date: 04/21/2023
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Scientific Updates (1)
- - IRAP for Veterinary Applications Scientific Update
  - File Type:
  - Ref. #: vDOC1-001110-en-US
  - Version: A
  - Language: English
  - Revision Date: 07/13/2023
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WebInHours (1)
- - Biologics Play a Role in Intraoperative and Postoperative Management in Tendon Injury
  - File Type:
  - Ref. #: vVID1-001432-en-US
  - Version: A
  - Language: English
  - Revision Date: 08/12/2020
  - Presenters: Samuel P. Franklin , DVM, Lauren Schnabel, DVM, DACVS, John Peroni, DVM, DACVS
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